Vinca Rosea, also called Periwinkle or Catharanthus Roseus,and sadabhar is an ornamental plant which is grown in gardens but has immense medicinal value.mainly helpful in the treatment of Cancer
Vinca Rosea Anti-cancer properties
The stems and leaves of Vinca Rosea contain anti-cancer alkaloids like Vinblastine and Vincristine, which inhibit the growth of certain human cancers.
How Vinca work In Cancer
The vinca alkaloids are cytotoxics – they halt the division of cells and cause cell death. During cell division, vinca alkaloid molecules bind to the building blocks of a protein called tubulin, inhibiting its formation. The drugs work during the M-phase of cell reproduction. Tubulin protein normally works in cells to create “spindle fibers,” (also called microtubules). These microtubules provide cells with both the structure and flexibility they need to divide and replicate. Without microtubules, cells cannot divide. by occupying tubulin’s building block structure, vinca alkaloids prevent cancer cells from successfully dividing.
Vinblastine inhibits angiogenesis, or the process by which new blood vessels grow from pre-existing ones. Angiogenesis is an essential step in a tumor’s transition to malignancy. Vinblastine is most often applied to treat
- Hodgkin’s disease
- Non-Hodgkin’s lymphoma
- Breast cancer
- Germ cell tumors.
Vincristine inhibition of microtubule formation is especially powerful. The reason for this comes from the fact that tubulin protein is dynamic. Its long chain of building blocks is always growing in some places and breaking in others. The less contiguous parts of a tubulin molecule have pieces only two building blocks long, called dimers. Vincristine has a high affinity for tubulin dimers, and the reaction between vincristine and the dimers is rapidly reversible. That means a vincristine molecule will attach to a dimer at one site, break off, and then reattach at another site. This keeps two sites per dimer “poisoned” and unable to reassemble into the protein. So vincristine’s ability to destabilize tubulin is especially good.
Vincristine is FDA approved to treat
- Acute leukemia
- Wilm’s tumor
- Hodgkin’s diseases and other lymphomas.
Vinca Alkaloid Side Effect
Vincristine’s most common side effects are: peripheral neuropathy, suppression of bone marrow activity, constipation, nervous system toxicity, nausea, and vomiting.
vinblastine side effect include: toxicity to white blood cells, nausea, vomiting, constipation, dyspnea, chest or tumor pain, wheezing, and fever. Vinblastine sometimes causes antidiuretic hormone secretion and angina.